![]() Patients with SLE are 11 times more at risk of presenting with valvular changes than healthy individuals. It has been suggested that some of the inherent SLE factors promote cardiovascular disease, such as the presence of antiphospholipid antibodies, reduced kidney function, disease duration, chronic damage to the organ reflected by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index, steroid duration and dose, and the use of azathioprine. 3 At present, the survival of patients with lupus has improved, but continuous cardiovascular morbimortality continues to be high, ranging between 17% and 76%, according to different studies. Symptomatic involvement detected ranged from 5% to 10% of patients, suggesting the subclinical nature of the damage to the myocardium. One of the major complications of SLE is cardiac involvement and this may affect all heart structures including the pericardium, myocardium, valves and coronary vessels to differing levels of severity, with the reported prevalence in autopsy studies ranging between 40% to 70%. 1 Damage to the cardiovascular system, apart from being primarily caused by an autoimmune/inflammatory process, is also associated secondarily with disease activity and severity, in addition to immunosuppressant treatment mostly with steroids. The presence of chronic inflammation may affect multiple organs, particularly the heart. Systemic lupus erythematosus (SLE) is an inflammatory immune disease characterised by the formation of autoantibodies and immune complex deposits. Los pacientes con lupus tienen menor deformación miocárdica de la AI, lo que se expresa como una menor función diastólica correlacionando con daño miocárdico subclínico precoz. También se encontró que en pacientes activos fue menor el SLGAI, en comparación con controles e inactivos. ![]() No hubo diferencias en la TSAI en ambos grupos (lupus 2,5 s-1 vs CS 2,75 s-1 p?=?0,1). Así como también fue menor en las 3 fases del ciclo de la AI. ResultadosĮl SGAI en pacientes con lupus fue menor al de CS (41,6% vs 50,5% p?=?0,02). La diferencia entre los grupos se analizó de forma univariante. Se midió por ecocardiograma transtorácico la deformación miocárdica mediante el strain global de AI (SGAI), el strain de las tres fases del ciclo de la AI y tasa de strain (TSAI). Se incluyeron 50 pacientes con LES y se compararon con controles sanos (CS) pareados por edad y sexo. Comparar el strain de la AI en pacientes con LES activos, inactivos y controles. ObjetivoĮvaluar la función de la AI mediante la deformación miocárdica, en pacientes con LES. Se ha visto que la deformación miocárdica de la aurícula izquierda (AI), mediante el strain longitudinal global de la AI (SLGAI), puede llegar a ser de utilidad en valorar la función diastólica. SLE patients have lower myocardial deformation of the LA, which is expressed as a lower diastolic function correlating with early subclinical myocardial damage.Įn los pacientes con lupus eritematoso sistémico (LES) la disfunción diastólica del ventrículo izquierdo (DDVI) puede ser la única manifestación de involucro cardiaco anticipando una disfunción sistólica. It was also found that the LAGLS was lesser in active patients than controls and inactive. ![]() There were no differences in the LA strain rate in both groups (SLE 2.5 s -1 vs controls 2.75 s -1 p?=?.1). LAGLS in SLE patients was less than in the controls (41.6% vs 50.5% p?=?.02), and in the 3 phases of the LA cycle. The differences between groups were compared in univariate analysis. ![]() Myocardial deformation was measured by transthoracic echocardiogram, to investigate the LAGLS, the strain of the three phases of the LA cycle and the strain rate. Methodsįifty patients with SLE were included and compared with 50 healthy controls paired by age and gender. To evaluate LA function through myocardial deformation in patients with LES, and compare the LA strain in patients with active, inactive and controls. It has been seen that myocardial deformation of the left atrium (LA), through the LA global longitudinal strain (LAGLS), may be useful in assessing diastolic function. In patients with systemic lupus erythematosus (SLE), left ventricle diastolic dysfunction (LVDD) may be the only manifestation of cardiac involvement in anticipation of systolic dysfunction.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |